New Orleans Saints
Grant was drafted by the Saints with the 25th pick overall in the 2002 NFL Draft. Grant's seven sacks in 2002 were the fourth-highest total for a Saints rookie, and he recorded 20.5 sacks from 2003-04. He was the second of two first-round picks (25th overall) for New Orleans in 2002, following wide receiver Donte' Stallworth (13th overall). He finished second with seven sacks for minus-40 yards, 36 tackles (32 solo), two passes defensed, four forced fumbles and one fumble recovery. Appeared in 16 games and started six at LDE. Finished tied for 20th in the NFC with seven sack total. Grant got a six-year extension with the Saints on July 27, 2002. After showing glimpses of his vast potential as a rookie, Grant came through with a big season and started all 16 games in 2003. He led the team with 10 sacks and three forced fumbles, and led the defensive line with 53 tackles (39 solo). He started all 16 contests for the second-straight season in 2004 and paced the defensive line with 113 tackles (69 solo) while posting a career-high 10.5 sacks. He also posted his first career interception. In 2005, hppeared in all 16 contests, starting 14 games at RDE, recording 62 tackles (44 solo), 2.5 sacks, two passes defensed and a fumble recovery. He bounced back from a relatively subpar seasonin 2006 with 6 sacks and 64 tackles (49 solo) in 16 games. He also collected 3 forced fumbles with 2 recoveries and 6 passes defensed. 2007 was Grant's worst season as a pro statistically, as he appeared in 14 of 16 games and compiled only 2.5 sacks to go along with 48 tackles (39 solo). He also chipped in with 2 passes defensed. Grant underwent surgery on a torn ligament in his left ankle the 2007-2008 offseason. Grant apparently injured his ankle on October 28, 2007 but was able to return after missing two games. The severity of the injury was known by the Saints, but never discussed with the media, and Grant admitted that he was not as sharp after the injury. On December 2, 2008, he received a four-game suspension for use of a diuretic, which can be used a masking agent for steroid use. It is believed that the diuretic was found in a weight-loss supplement that he had been taking. Charles Grant was due to be suspended for the first 4 games of the Saints' 2009 season, but the league has delayed suspension pending the outcome of a filed litigation by Kevin Williams and Pat Williams of the Minnesota Vikings, who were also accused for using the same diuretic. After starting at left defensive end throughout the regular season, he went on injured reserve for the playoffs with a torn triceps. (He nevertheless received a Super Bowl ring in recognition of his role in the Saints' championship season.) Grant was released by the Saints on March 5, 2010.
After he left the Saints, Grant briefly appeared on the roster of the Omaha Nighthawks of the United Football League, but he did not actually join the team once it appeared that he could continue with an NFL career. Grant signed a two-year contract with the Miami Dolphins on July 28, 2010. The Dolphins cut Grant on September 5, 2010.
Grant signed with the Omaha Nighthawks of the United Football League on September 21, 2010.
Grant signed with the Chicago Bears of the National Football League on October 5, 2010. He was released on October 19